Research teams

Cell Differentiation and Polarity

DIPOL 9 members

Post-doctoral position in modeling metabolic fluxes

Institut Jean-Pierre Bourgin (IJPB), Versailles, France

A position of bioinformatician researcher with expertise in machine or deep learning algorithms applied to omics data is opened at IJPB. The analysis of metabolic flux is now essential to understand specialized metabolisms but also to propose efficient engineering approaches. Non-targeted metabolomic data directly provide a stationary picture of the whole metabolism but can now lead to dynamic models in particular of fluxes. New algorithmic approaches inspired by artificial intelligence (machine or deep learning) coupled with the association of constrained metabolic models allow the creation of genome-wide metabolic models to predict more efficiently metabolite flux.

The first objective will be to inventory and test the methods coupling Flux Balance Analysis (FBA) and computational based modeling (CBM) already available and for the most part developed for microorganisms. Limited number of specialized metabolic datasets (e.g. under biotic or other constraints) will be use to train and to evaluate the different methods and tools available. The position will benefit from the support of the chemistry platforms and the bioinformatics and statistical modeling teams of Saclay Plant Sciences (SPS) network as well as collaborations with groups outside SPS.

The SPS network (SPS; www.saclayplantsciences.fr) brings together about fifty research teams specializing in plant sciences spread over several sites within the perimeter of the University of Paris-Saclay. Two of the flagship projects of SPS concern specialized metabolites produced by plants and plant pathogenic fungi (under the responsibility of the MetaSpé Working Group) and bioinformatics and bioanalysis tools to be developed within the framework of research conducted in the network.

Application should include a cover letter and a detailed CV including two scientific references that must be sent to jean-denis.faure@inrae.fr.

Applications will be accepted until the position is filled. Selected candidates will be invited for an interview.



Starting date: from 01/04/2021 – one year contract

Salary: 2400 - 2600 euros (according to previous professional experience).

Expertise or training in statistical modeling is desired and experience in metabolic flow analysis would be appreciated.
Cell Differentiation and Polarity

Leader:

Jean-Denis Faure
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