IJPB / SPS Seminar Dr François Nédélec
Modelling microtubules in plants: mitotic spindles and the interphase cortical array - Thursday, 2nd April 2026 11 am, INRAE, Versailles
How models describing the dynamics of microtubule systems in plants can be built from experimental observations?
Mitotic spindles stands out as an ideal subject to build a quantitatively accurate 3D simulation. I will present our attempts to build such a model, detailing some key assumptions and illustrating the remarkable dynamics of metaphase mitotic spindles.
Cortical microtubules are an important system within plant cells, as it governs cellular expansion and thus ultimately the morphology of all plants. Our 3D force-based model shows that Collision-induced catastrophes, which contribute to the removal of misaligned microtubules, produce disorganized arrays, whereas the addition of katanin-mediated severing generates aligned microtubules.
François Nédélec, Sainsbury Laboratory, University of Cambridge, Cambridge, UK
Invitation : Magalie Uyttewaal, "Spatial Control of Cell Division" SPACE team
Seminar in connection with the research developed at the Institute Jean-Pierre Bourgin for Plant Sciences.
Mitotic spindles stands out as an ideal subject to build a quantitatively accurate 3D simulation. I will present our attempts to build such a model, detailing some key assumptions and illustrating the remarkable dynamics of metaphase mitotic spindles.
Cortical microtubules are an important system within plant cells, as it governs cellular expansion and thus ultimately the morphology of all plants. Our 3D force-based model shows that Collision-induced catastrophes, which contribute to the removal of misaligned microtubules, produce disorganized arrays, whereas the addition of katanin-mediated severing generates aligned microtubules.
François Nédélec, Sainsbury Laboratory, University of Cambridge, Cambridge, UK
Invitation : Magalie Uyttewaal, "Spatial Control of Cell Division" SPACE team
Seminar in connection with the research developed at the Institute Jean-Pierre Bourgin for Plant Sciences.
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