Seminar Dr. Jean Molinier

In the last decades many studies reported evidence for various interplays between DNA repair pathways and the shape of the epigenomic landscape. This includes the epigenetically related DNA damageability, the specific damage repair processes and the role of these interconnected mechanisms in (epi)genome maintenance and plasticity. Interestingly, the epigenetic context of the damaged genomic regions defines by which repair pathways lesions will be processed. For example, UV-induced DNA damage occurring in genomic regions with an epigenetic landscape allowing transcription are repaired by the Transcription Coupled Repair pathway. Conversely, the compacted heterochromatic regions, un-transcribed or poorly transcribed, are predominantly repaired by the Global Genome Repair. The exact mechanisms by which these repair pathways recognize and process photodamaged DNA sequences wrapped around nucleosomes remain to be better deciphered. In addition, the accurate re-establishment of the epigenomic landscape upon repair appears to be an important step in the maintenance of (epi)genome integrity and relies on different photodamage repair processes. Thus, in the group we aim at deciphering the molecular mechanisms involved in the repair of UV-induced DNA damage and their interconnections with the epigenome maintenance pathways.

Webpage "Plant epigenetic regulation and inheritance" team of Jean Molinier and Wen Hui Shen, the "Institut de biologie moléculaire des plantes" IBMP

Invitation : Martin Lacroix and Hervé Vaucheret