Seminar Simone Köhler
The complex regulation of crossover formation in C. elegans - Friday 13th December 2024, 11:00 am
The Köhler group studies how chromatin is organised during meiosis to allow for the production of haploid gametes from diploid precursor cells.
Meiosis is a specialised cell division process that generates haploid gametes from diploid precursor cells. During the meiotic cell division process, homologous chromosomes undergo recombination and are then segregated from each other. Errors in this process are a major cause of infertility and can also result in congenital conditions such as Down syndrome. For homologous chromosomes to segregate properly during meiotic divisions, they must first pair during meiotic prophase. Pairing is ultimately stabilised by crossover formation, which generates physical linkages between the homologous chromosomes and gives rise to genetic diversity. More on Köhler Group
Simone Köhler, Self-organisation in meiosis, EMBL Heidelberg, Germany
Invitation: Mathilde Grelon, contact, "Meiosis Mechanisms" MeioMe team
In connection with the research developed at the Institute Jean-Pierre Bourgin for Plant Sciences.
Meiosis is a specialised cell division process that generates haploid gametes from diploid precursor cells. During the meiotic cell division process, homologous chromosomes undergo recombination and are then segregated from each other. Errors in this process are a major cause of infertility and can also result in congenital conditions such as Down syndrome. For homologous chromosomes to segregate properly during meiotic divisions, they must first pair during meiotic prophase. Pairing is ultimately stabilised by crossover formation, which generates physical linkages between the homologous chromosomes and gives rise to genetic diversity. More on Köhler Group
Simone Köhler, Self-organisation in meiosis, EMBL Heidelberg, Germany
Invitation: Mathilde Grelon, contact, "Meiosis Mechanisms" MeioMe team
In connection with the research developed at the Institute Jean-Pierre Bourgin for Plant Sciences.
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Legend: The model organism C. elegans to study meiosis. The majority of cells (nuclei shown in cyan) in adult C. elegans hermaphrodites are germ cells. We use a variety of fluorescence microscopy techniques such as Airyscan imaging (left inset; chromatin in cyan, synaptonemal complexes are shown in orange) and single-molecule localisation microscopy (right inset) to study the function and dynamics of chromosome organisation during meiotic prophase.