Seminar Dr. Leandro Quadrana

Transposable elements (TEs) are repetitive DNA sequences capable of mobilizing across genomes, potentially creating large-effect mutations. To suppress such a threat, TEs are typically controlled epigenetically by chromatin modifications, including DNA methylation. Epigenetic silencing of TEs can also affect the expression of nearby genes, and thus changes in DNA methylation can lead to TE reactivation and modulation of gene expression. However, how, and when DNA methylation changes occur in nature, and what are the consequences of such changes remain poorly understood. In this talk I will present our efforts to characterize the rate, landscape, and impact of natural variation in TE silencing and mobilization in Arabidopsis and Tomato.

Dr. Leandro Quadrana, leader of the "Plant Quantitative genomics and epigenomics"  Q-Lab team, "Institute of Plant Science Paris-Saclay" IPS2, University of Paris-Saclay, France
Guest collaborating on research developed at the Institute Jean-Pierre Bourgin for Plant Sciences.

Invitation: Nicolas Bouché, "Epigenetic Natural Variation" VarEpi